Mapping the brain networks

The advancement of new technologies enables better understanding and more precise localisation of epilepsy. Epilepsy surgery offers a potential cure for focal epilepsy. SEIN has an active presurgical work-up, including video-EEG monitoring, MRI post-processing, neuropsychological testing, nuclear imaging (PET/SPECT), and invasive EEG recording in collaboration with UMC Utrecht. Focus localisation is being improved through multimodal imaging, advanced EEG signal analysis (modelling, networks, high-frequency oscillations), MEG, TMS-EEG, and intra-operative guidance. Innovative neurotechnologies can also elucidate the networks involved in sleep pathology, including the metabolic and neurohumoral factors that modulate sleep propensity.
Our sleep research focuses on hypocretin deficiency and narcolepsy: the presumed autoimmune cause of narcolepsy; the role of hypocretin beyond the regulation of sleep and wakefulness, particularly its role in metabolism; and the interaction between sleep and metabolism.

Projects

Details of the projects included in this programme will be available here shortly.